Current and Past Research
Arkansas State University
Novel Synthesis and Effects of Secondary Amine Substituted Thiazoles
We are currently exploring the design and synthesis of secondary amine-substituted thiazoles, leveraging their bioactive potential in medicinal chemistry. Our synthetic approach enables efficient production of these derivatives on gram scale, previous compounds have shown antimicrobial and anticancer effects in assays. Ongoing studies aim to optimize their pharmacological profiles and evaluate their therapeutic applications in murine mouse models.
Synthesis and Evaluation of Chlorine-Substituted Pyrazole Molecules for Antibacterial Applications
This research focuses on developing chlorine-substituted pyrazole molecules with promising antibacterial properties. Using reductive amination and the Vilsmeier–Haack reaction, we have created derivatives that demonstrate very strong antibacterial potential against gram positive and negative bacteria in MIC and MBC assays. Future work involves in vivo murine mouse model studies to test toxicity and efficacy.
Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities
In our recent publication, "Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents," we introduced an efficient one-pot synthetic method for creating benzothiophene derivatives. This streamlined approach enhances the synthesis process by reducing the number of steps and overall reaction time. The resulting benzothiophene compounds were evaluated for their biological activity, revealing promising potential as therapeutic agents. This work contributes to the development of new methodologies in organic synthesis and the discovery of novel compounds with potential applications in medicine.